<p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; clear: both; color: rgb(51, 51, 51); font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; font-size: 17px; text-align: justify; white-space: normal;">&nbsp; 为革兰阴性杆菌，病变中渗出液粘稠而重，致使叶间隙下坠。细菌具有荚膜，在肺泡内生长繁殖时，引起组织坏死、液化、形成单个或多发性脓肿。病变累及胸膜、心包时，可引起渗出性或脓性积液。病灶纤维组织增生活跃，易于机化；纤维素性胸腔积液可早期出现粘连。

<p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; clear: both; color: rgb(51, 51, 51); font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; font-size: 17px; text-align: justify; white-space: normal;">呼吸机相关性肺炎 (ventilator associated pneumonia，VAP) 指气管插管或气管切开患者在接受机械通气 48 h 后发生的肺炎，是重症医学科 (ICU) 内患者最常见的院内获得性感染之一。VAP 在国内外报道的发生率和病死率均较高。

<p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; clear: both; color: rgb(51, 51, 51); font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; font-size: 17px; text-align: justify; white-space: normal;"><strong style="margin: 0px; padding: 0px;">铜绿假单胞菌（P.Aeruginosa）</strong></p><p style="margin-top: 0px; margin-bottom: 0px; padding:

<p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; clear: both; color: rgb(51, 51, 51); font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; font-size: 17px; text-align: justify; white-space: normal;">随着对高危、难治或复发儿童白血病等恶性肿瘤化疗强度的增大及异基因造血干细胞移植的应用，儿童侵袭性真菌病（IFD）的发生率逐年上升，成为影响患儿预后的重要因素之一。IFD 系真菌侵人人体组织、体液、血液，并在其中生长繁殖导致组织损害、器官功能障碍及炎症反应的病理改变及病理生理过程 [1]。

<p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; clear: both; color: rgb(51, 51, 51); font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; font-size: 17px; text-align: justify; white-space: normal;"><span style="margin: 0px; padding: 0px; max-width: 100%; font-size: 13px; word-wrap: break-word !important; box-sizing: border-box !important;">&nb

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<p style="margin-top: 0px; margin-bottom: 0px; padding: 5px 0px; clear: both; text-align: justify; white-space: normal; font-size: 14.2857px; font-family: Tahoma, Helvetica, Arial, sans-serif; text-indent: 2em; color: rgb(42, 42, 42); line-height: 24.9851px; background-color: rgb(245, 250, 255);"><span style="margin: 0px; padding: 0px; font-family: 楷体_GB2312; font-size: 19px;">真菌药物的临床应用与早期诊断治疗的意义<br/><img src="

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